Biography
Background
I am a statistician with interests in methods for improving the design and analysis of clinical trials. As well as working in methodology development I have a great interest in collaborating on real trials to apply new methods in practice.
I have been at Newcastle University since July 2017.
Areas of expertise
- Biostatistics
- Clinical trials
- Novel trial design
Research
My research focuses on statistical methods for improved design and analysis of clinical trials. I am particularly interested in:
- Adaptive designs for clinical trials;
- Methods for incorporating biomarkers into clinical trials to stratify patients by treatment response;
- Improved methods for analysing composite endpoints, in particular ones with continuous components.
Scopus: Click here
Contact
- Email: james.wason@ncl.ac.uk
- Telephone: +44 (0) 191 208 3699
- Address: Population Health Sciences Institute, 4th Floor Ridley Building 1, Queen Victoria Road, Newcastle upon Tyne NE1 7RU, UK
FAQs
Q: How do you pronounce your surname?
A: It rhymes with Mason, like ‘Way-son’.
Publications
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(2024).
Adaptive and innovative study design in rare diseases.
Archives of Disease in Childhood.
(2024).
Challenges of designing and conducting cohort studies and clinical trials in populations of pregnant people.
The Lancet Rheumatology.
(2024).
Graves-PCD: protocol for a randomised, dose-finding, adaptive trial of the plasma cell-depleting agent daratumumab in severe Graves’ disease.
BMJ Open.
(2024).
Extracorporeal photopheresis (ECP) in the treatment of chronic lung allograft dysfunction (CLAD): a prospective, multicentre, open-label, randomised controlled trial studying the addition of ECP to standard care in the treatment of bilateral lung transplant patients with CLAD (E-CLAD UK).
BMJ Open Respiratory Research.
(2024).
Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions.
BMJ Open.
(2024).
The mediating role of reflective functioning and general psychopathology in the relationship between childhood conduct disorder and adult aggression among offenders.
Psychological Medicine.
(2024).
Pulmonary Hypertension: Intensification and Personalization of Combination Rx (PHoenix): A phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies.
Pulmonary Circulation.
(2023).
Utilising high-dimensional data in randomised clinical trials: A review of methods and practice.
Research Methods in Medicine & Health Sciences.
(2023).
Online Multiple Hypothesis Testing.
Statistical Science.
(2023).
A Comparison of Randomization Methods for Multi-Arm Clinical Trials.
Statistics in Biopharmaceutical Research.
(2023).
The potential of innovative trial design for efficiently evaluating repurposed drugs.
Nature Reviews Drug Discovery.
(2023).
Current practices in studies applying the target trial emulation framework: a protocol for a systematic review.
BMJ Open.
(2023).
Bayesian borrowing for basket trials with longitudinal outcomes.
Statistics in Medicine.
(2023).
A randomised study of rituximab and belimumab sequential therapy in PR3 ANCA-associated vasculitis (COMBIVAS): design of the study protocol.
Trials.
(2023).
A novel nano-iron supplement versus standard treatment for iron deficiency anaemia in children 6–35 months (IHAT-GUT trial): a double-blind, randomised, placebo-controlled non-inferiority phase II trial in The Gambia.
eClinicalMedicine.
(2022).
Point estimation following a two-stage group sequential trial.
Statistical Methods in Medical Research.